The Effects of Oxalis corniculata l. Extract against MPTP Induced Oxidative Stress in Mouse Model of Parkinson’s Disease

نویسندگان

  • K. Aruna
  • P. Devi
  • Raja Rajeswari
  • S. Raja Sankar
چکیده

Neurodegeneration refers to a condition of neuronal death occurring as a result of progressive disease of long term. It involves degeneration of circumscribed group of neurons that may be functionally or neuroanatomically connected. Parkinson’s disease (PD) is a chronic, progressive neurological disorder. Recent studies have indicated that a part of active compounds extracted from herbal medicines, herbal extracts and herbal formulations have effects on Parkinson disease models in vitro and in vivo. The present study deals with the effects of Oxalis corniculata L. extract against MPTP induced oxidative stress in mouse model of Parkinson’s disease. O. corniculata extract at doses of 250 and 500 mg/kg along with MPTP administration significantly restored the peroxides and antioxidant levels to near normal in the brains of the test animals. The standard drugs L-dopa + carbidopa combination also significantly restored the peroxides and antioxidant levels to near normal.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The effects of aqueous cinnamon bark extract and cinnamaldehyde on neurons of substantia nigra and behavioral impairment in a mouse model of Parkinson’s disease

Background and Objective: Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons in substantia nigra. In recent years, there have been interests in the role of the free radical damage in PD. Cinnamon and its derivative, cinnamaldehyde acts as powerful antioxidant and anti-inflammatory agents. This research focused on the effects of cinnamon extract and cinnamald...

متن کامل

Peganum Harmala L. Extract Reduces Oxidative Stress and Improves Symptoms in 6-Hydroxydopamine-Induced Parkinson’s Disease in Rats

Parkinson’s disease is one of the most common neurodegenerative disorders.  There are many documents about the effects of oxidative stress in Parkinson’s disease etiology. Angiotensin II activates NADPH dependent oxidases and causes superoxides formation.  Peganum harmala L. extract, which has angiotensin converting enzyme (ACE) inhibitory effect, is considered to evaluate oxidative stress inhi...

متن کامل

Cinnamaldehyde attenuates dopaminergic neuronal loss in substantia nigra and induces midbrain catalase activity in a mouse model of Parkinson’s disease

Background and Objective: Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease that affects 3% of the population. PD involves a progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) and subsequent loss of dopamine. Dopamine depletion leads to movement dysfunction and is accompanied with tremor, rigid muscle...

متن کامل

Peganum Harmala L. Extract Reduces Oxidative Stress and Improves Symptoms in 6-Hydroxydopamine-Induced Parkinson’s Disease in Rats

Parkinson’s disease is one of the most common neurodegenerative disorders.  There are many documents about the effects of oxidative stress in Parkinson’s disease etiology. Angiotensin II activates NADPH dependent oxidases and causes superoxides formation.  Peganum harmala L. extract, which has angiotensin converting enzyme (ACE) inhibitory effect, is considered to evaluate oxidative stress inhi...

متن کامل

Arbutin attenuates behavioral impairment and oxidative stress in an animal model of Parkinson's disease

Objective: Arbutin has been shown to have antioxidant and free-radical scavenging properties. The aim of this study was to investigate the effects of arbutin administration on behavioral impairment, and oxidative and nitrosative stress in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced animal model of Parkinson’s disease (PD). Materials and Methods: PD model was developed by 4 int...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016